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PrimoGAIA 3rd Steering Committee meeting
22 septembre 2022
1st Workshop on Emerging Trends in Molecular Imaging 2023
23 février 2023
2 février 2023

A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging

Published in the Journal of Magnetic Resonance

Abstract:

Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes.

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 863099