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PrimoGAIA 3rd Steering Committee meeting
22 septembre 2022![](https://www.primogaia.eu/wp-content/uploads/2023/02/locandina-WP-imaging2023.jpg)
1st Workshop on Emerging Trends in Molecular Imaging 2023
23 février 2023Published in the Journal of Magnetic Resonance
Abstract :
Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes.